Abstract:【Abstract】 Objective To investigate changes of plasma endotoxin, interleukine6 (IL6), tumor necrosis factoralpha (TNFα) and procalcitonin (PCT) levels in paraplegic rabbits treated with selective digestive decontamination (SDD).Methods Animals were subjected to a complete paraplegia following spinal cord injury, and divided into SDDtreated and control groups. The treatment group received SDD using PTA protocol by gavage three times daily for 4 days after injury. The control group was given the same amount of normal saline. Plasma were collected to detect ET, IL6, TNFα and PCT concentrations, and samples from the small intestine were collected to assess morphological changes, using Hematoxylin and eosin staining. The correlation between ET, IL6, TNFα and PCT levels and the degree of intestinal mucosal damage were analyzed. Results Plasma ET concentration in SDD group was significantly lower than that in control group [(015(005) EU/ml vs (057(011) EU/ml, t=15341, P<0001). In addition, plasma IL6, TNFα, and PCT levels in SDD group were also obviously lower that in control group. Correlation analysis showed ET, IL6, TNFα and PCT levels were positively correlated with the degree of intestinal mucosal injury (P<005). Conclusion SDD alleviates systematic inflammatory reaction and decreases endotoxin translocation from the intestinal tract in rabbits with complete paraplegia.