【Abstract】 Objective To explore and analyze the effect of the combination of non spot and Diver thrombus aspiration catheter on myocardial reperfusion in patients with acute ST segment elevation myocardial infarction. Methods 84 patients with acute ST elevation myocardial infarction need percutaneous coronary artery interventional therapy (percutaneous coronary, intervention, PCI) from January 2012 to January 2016 were included in the present study. The patients were diagnosed as coronary artery thrombosis and randomly divided into observation group and control group, 42 cases in each group. Patients in the control group were treated with Diver thrombus aspiration catheter in PCI operation, and the observation group was treated with DiverCE thrombus aspiration catheter aspiration combined with PCI in the observation group. The two groups according to the situation, select the appropriate stent or balloon dilation after stent implantation, the two groups were observed and recorded in the 90min ST fall, corrected TIMI frame count (CTFC), bleeding related complications before and after surgery, coronary blood flow, and postoperative adverse cardiovascular events. Results The ST moving down in 90 min and CTFC of observation group and control group was significantly different (p<0.05). The ST moving down in 90 min of observation group was higher than that of control group (p<0.05). CTFC of observation group was lower than that of control group (p<0.05). The difference of TIMI blood flow classification of observation group and control group was not obvious (u=0.59, p>0.05). Differences of TIMI blood flow were significantly different (u=6.75, p<0.05) in two groups after operation. There was no significant difference in the incidence of sudden cardiac death and non fatal myocardial infarction between the two groups (p>0.05). The control group of patients with recurrent ischemic angina incidence rate was19.0%, the observation group was 2.4%, significantly lower than the control group (X2=5.44, p<0.05). The incidence of reperfusion arrhythmias in the observation group was significantly lower than that in the control group (p<0.05). Gingival bleeding, hematoma puncture points, urine occult blood, fecal occult blood, the total bleeding rate in two groups had no significant difference (p>0.05), with no statistically significant. Conclusion The interventional treatment of Diver thrombus aspiration catheter combined with non spot can effectively improve the blood flow in patients with acute myocardial infarction, but it does not increase the risk of bleeding.