【Abstract】 Obejective To analyze the differences in perioperative period of esophagogastric junction carcinoma resection, and to provide reference for clinical surgical strategy.Methods 144 clinical data of esophagogastric junction carcinoma resection were divided into the surgical approach of transhiatal group (A group, 96 cases), IvorLewis group (B group, 36 cases) and transthoracic group (C group, 12 cases). The operation time, blood loss, postoperative complication rate, the length of tumor resection margin，the degree of lymph node dissection and the average length of stay were analyzed.Results The operation time of group B (3092±659min) was longer than that of group C (205± 731min) and group A (1969± 533min). The postoperative drainage of group B (3641±2953ml) was more than that of group C (165±1410ml) and group A (1628±1192ml). The length of tumor resection margin of group A (219±029cm) was shorter than that of group B (360±041cm) and group C (347±048cm). The incidence of postoperative pleural effusion of group B（222%）was greater than group that of group A（52%）and group C（83%）. The average length of stay of group B (241±39）was greater than that of group A（217±26）and group C (227±33）. All the differences were statistically significant. The total number of lymph nodes of group A, group B and group C were 0, 133±023 and 100±00. The carina lymph node metastasis of group A, group B and group C were 0%, 166% and 167%,respectively. The total number of lymph node dissection, the degree of lymph node metastasis, the incidence of postoperative pulmonary infection, anastomotic fistula rate, postoperative plasma albumin levels, anastomosis methods and incidence of chylothorax or chylous abdomen of group A, group B and group C had no significant differences.Conclusion Although the IvorLewis surgery increased the perioperative trauma and postoperative complications, but no substantive differences with other approaches, and can fully clean the lymph nodes, especially the mediastinal lymph nodes above the site of carina. Based on oncology requirements, the IvorLewis maybe the most suitable approach for the esophagogastric junction tumor surgery.