【Abstract】 Objective To explore the clinical effect of ginkgolide injection on acute cerebral infarction. Methods We selected 178 acute cerebral infarction patients treated in our hospital from August 2013 to May 2015 as the research object. All the patients were divided into experimental group (92 cases) and control group (86 cases) according to the method of random Numbers table. And the control group patients treated on a regular treatment, the experimental group treated on the regular treatment combined ginkgolide injection. To compared the clinical effects with the two groups of patients, and we take NIHSS score to evaluate neurologic deficits in patients before and after treatment, take Barthel index scale to assess patients daily life ability before and after treatment as well as evaluate neurologic functional recovery after treatment in patients with mRS score. Results The study found that the experimental group total effective rate (8587%) was significantly higher than that of control group (7442%), p＜005, the difference is statistically significant; NIHSS score and Barthel index scale of two groups of patients before treatment had no obvious difference, p > 005, but those of two groups of patients were significantly improved after treatment, and the experimental group is better than that of control group. The number of mRS score 02 points in experimental group is significantly more than that of control group after treatment, p＜005, the difference is statistically significant. Conclusion The treatment clinical effect of ginkgolide injection on acute cerebral infarction is remarkable, can well improve the patients' neurologic deficits, and can improve patients' daily life ability. It has high clinical value, which can be widely applied.