【Abstract】Cardiac fibrosis, closely related to the occurrence of heart failure, is not only the key process, but the causality of nearly all forms of heart disease. Many pathological conditions can cause cardiac fibrosis, such as myocardial injury, overload pressure and so on. With the development of cardiac fibrosis, many cytokine are involved, such as transforming growth factor β, angiotensin II, reactive oxygen species and so on, these factors mediated cardiac fibrosis through the same or different signal pathway. It is necessary to explore signal transduction pathway of cardiac fibrosis and potential therapies that effectively target cardiac fibrosis, we may get a breakthrough in the treatment ofheart disease.