【Abstract】 Objective To analyze the influence of comprehensive rehabilitation nursing mode on neural function in patients with cerebral infarction and the influence of the quality of life. Methods 80 patients with cerebral infarction were selected as clinical nursing subjects admitted in our hospital during April 2013 to May 2015, using the random number method. The patients were divided into observation group and the control group, each group of 40 cases. Observation group was treated with comprehensive rehabilitation nursing intervention. Control group was treated with routine nursing treatment. The patients' satisfaction to nursing, clinical total effective rate of neural functional recovery, Barthel index (MBI) score, Chinese stroke scale (CSS) evaluation and selfevaluation of anxiety scale (SAS), depression self rating scale (SDS) score and SF36 life quality evaluation scale score were observed.Results After different intervention nursing mode, the total clinical effective rate of recovery of neurological functions in rehabilitation nursing group was significantly higher than that in the conventional nursing group (P<005). The total satisfaction of nursing of observation group was obviously higher than that of control group (P<005). After intervention, CSS scores of the two groups were lower (P<005), and MBI scores were increased (P<005). CSS score of the observation group was lower than that of the control group (P<005). MBI scores of the observation group was higher than that of the control group (P<005). SAS and SDS scores after intervention were lower than that before intervention (P<005). SAS and SDS score of the intervention group were lower than that of control group (P<005). After the intervention, SF36 scale scores of physiological function, physical function, mental health, emotional function, vitality and general health status and social functions were increased (P<005).The quality of life score was different before and after intervention (P<005).Conclusion The treatment of patients with comprehensive rehabilitation nursing can significantly improve patients with nerve function and quality of life.