【Abstract】 Objective To investigate the effects of quetiapine combined with oryzanol on clinical symptoms and blood glucose and lipid metabolism in elderly schizophrenic patients. Methods 120 elderly schizophrenic patients treated in our hospital from December 2013 to December 2015 were randomly divided into experimental group and control group, 60 cases in each group. The experimental group received quetiapine combined with oryzanol treatment. The control group were treated with quetiapine. The efficacy was evaluated by using the clinical impression scale (CGI), positive and negative symptom scale (PANSS) and treatment emergent symptom scale (TESS)fasting blood glucose (FBG), total triglyceride (TG) ,total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL). The effects of drugs on the metabolism of glucose and lipid were observed. Results After the treatment, the PANSS scores and CGI scores of the two groups were significantly decreased (P<0.05). The CGI scores of the patients in the experimental group were lower than those in the control group at the same time point after the treatment (P<0.05). There was no significant difference between the two groups of patients after one course of treatment and four courses of treatment (P>0.05). The adverse reactions of the treatment group were significantly lower than those of the control group after two courses of treatment and three courses of treatment (P<0.05). There were no significant differences in TG, TC ,FBG,HDL and LDL between the two groups before and after treatment (P>0.05). After four courses of treatment, the average fasting blood glucose level was significantly increased in the two groups (P<005). Conclusion The results of this study show that the application of quetiapine and oryzanol can effectively improve symptoms, and improve drug safety. The effect on basal metabolism is relatively small.