【Abstract】 Objective To investigate the clinical characteristics of patients with sellar meningiomas and the influencing factors of prognosis. Methods 45 patients with sellar meningiomas were retrospectively analyzed admitted in our hospital from November 2009 to December 2010. The clinical data of patients with sellar meningiomas were collected and analyzed. 45 patients with sellar meningioma were followed up for 4 to 59 months. The mean followup time was (21.09±10.64) months. The Karnofsky functional status scale was used to evaluate the quality of life in 45 patients with sellar meningioma. Logistic regression was used to analyze the factors influencing the quality of life of patients with sellar meningiomas. Results Among 45 patients with saddle area meningioma, 77.77% (35/45) of them had vision disorder as the main clinical symptom. Among them, 7555% (34/45) had visual field disorder, 86.66% (73.33%) patients had headache, a small number of patients had ophthalmoplegia, nausea, vomiting, personality changes, fatigue, lethargy, eyeballs. Meningioma center was located in the center of the eye. Saddle nodules were much, reaching 31.11%, 48.88% (22/45) of the lesion diameter ≤ 3cm. The total resectable rate of tumor (Simpson Ⅰ~Ⅲ) was 77.77%. The resection rate (Simpson Ⅳ) was 22.22%. One patient (2.22%) died after operation. The results of univariate analysis showed that KPS score, visual acuity after operation, relationship between tumor and pituitary stalk, tumor growth direction, relationship between tumor and internal carotid artery and its branches and operation were influence factors (P<0.05). Multivariate logistic regression analysis showed that the postoperative visual acuity of the patients was significantly higher than that of the pituitary stalk (P <0.05). The postoperative quality of life was significantly correlated with the postoperative quality of life. The relationship between the tumor and the internal carotid artery and its branch, and the degree of tumor resection is an independent risk factor influencing the quality of life of postoperative patients (P<0.001). Conclusion Saddle area meningioma patients with visual impairment is the main clinical features, and more common in patients with headache symptoms. The postoperative visual acuity, the relationship between the tumor and the pituitary stalk, the relationship between the tumor and the internal carotid artery and its branches, and the degree of resection of the tumor are independent risk factors influencing the postoperative quality of life of the patients.