基质金属蛋白酶-7在鼻咽癌中的表达及其与肿瘤侵袭转移的相关性研究
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南充市科技局项目(16YFZJ0021);川北医学院博士科研启动项目(CBY13-QD-08)


Expression of matrix metalloproteinase-7 in nasopharyngeal carcinoma and its relationship with invasion and metastasis of nasopharyngeal carcinoma
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    摘要:

    【摘要】 目的 评价基质金属蛋白酶-7(MMP-7)在鼻咽癌中的表达及其与肿瘤侵袭转移的相关性。方法 选取2014年5月~2015年12月我院收治的鼻咽癌患者39例作为观察组,同期收治的慢性鼻咽炎患者35例作为对照组,测定MMP-7在两组患者中的表达情况,并对观察组内不同分期患者的MMP-7表达情况进行比较。结果 观察组患者MMP-7表达明显高于对照组患者,差异有统计学意义(P<0.05);MMP-7在鼻咽癌Ⅰ期和Ⅱ期患者中的阳性率为526%,在鼻咽癌Ⅲ期和Ⅳ期患者中的阳性率为95.0%,Ⅲ期和Ⅳ期患者中的MMP-7阳性率明显高于Ⅰ期和Ⅱ期患者,差异有统计学意义(P<0.05)。结论 MMP-7在鼻咽癌患者中具有较高的阳性表达率,其表达随着患者肿瘤的浸润深度、淋巴结转移范围而提高,可将MMP-7作为鼻咽癌诊断以及恶性程度预测的重要观察指标,为临床诊断提供客观可靠的依据。

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    【Abstract】 Objective To evaluate the expression of matrix metalloproteinase-7 (MMP-7) in nasopharyngeal carcinoma and its relationship with invasion and metastasis of nasopharyngeal carcinoma.Methods 39 patients with nasopharyngeal carcinoma from May 2014 to December 2015 in our hospital were selected as observation group. 35 chronic pharyngitis patients at the same period were selected as control group. The expression of MMP-7 at different stages were observed.Results The expression of MMP-7 of observation group was significantly higher than that of control group. The difference was statistically significant (P<0.05). The positive rate of MMP-7 in patients with nasopharyngeal carcinoma at stage I and stage II was 526%. The positive rate in patients with nasopharyngeal carcinoma at stage III and stage IV was 95%. The positive rate of MMP-7 of patients at stage III and stage IV was higher than that at stage I and stage II . The difference was statistically significant (P<0.05).Conclusion The positive expression of MMP-7 is high. The expression rate increases with the depth of tumor invasion, lymph node metastasis and the wide range. MMP-7 can be used as an important index of observation and prediction of malignancy in the diagnosis of nasopharyngeal carcinoma.

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  • 在线发布日期: 2017-06-20
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