【Abstract】 Objective To screen the genes involved in childhood obesity and explore the pathogenesis mechanism of childhood obesity.Methods〓The dataset GSE9624 containing the gene expression profiles of obese children was downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were screened using BRB. Array Tools software, then the GO function, KEGG enrichment analysis, and pathway relation network analyses were performed based on these differential genes.Results〓Totally, 564 differential genes were identified, of which 333 genes were upregulated and 231 genes were downregulated.GO en richment analysis showed that DEGs mainly participated in biologicaI process of metabolic process, response to cytokine stimulus, signal transduction, blood coagulation, and performed the molecular functions of protein binding, protein homodimerization activity, ion binding, RNA binding, and ATP bindingKEGG enrichment analysis suggested that DEGs were involved in metabolic pathways, MAPK signaling pathway, phagosome, protein processing in endoplasmic reticulum and T cell receptor signaling pathway.Conclusion 〓Genes involved in metabolic and signalling pathways are altered in obese children, which provides the foundation for further understanding the molecular pathogenesis of childhood obesity and developing treatments for this disorder.