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PPAR γ与纤维化疾病关系研究进展
雷蕾
0
(四川大学华西医院烧伤整形科)
摘要:
【摘要】 纤维化疾病是临床上常见的疾病,至今仍是一个治疗难题。近年来的研究发现,过氧化物酶体增殖物激活受体(PPARs)中PPARγ亚型的活化或激动剂在器官纤维化的发生过程中有调节作用,可减缓纤维化进程。本文就PPARγ与肝、肾、肺、心肌、眼及皮肤等器官纤维化发病关系的研究现状与进展做一综述。
关键词:  PPAR γ  肝纤维化  肾纤维化  肺纤维化  皮肤纤维化
DOI:
基金项目:国家自然科学基金(81101180,81171822,81571915);四川省科技厅应用基础项目(2016JY0153)
Research progress in the correlation between peroxisome proliferator activated receptor gamma and fibrotic diseases
LEI Lei
(Department of Burn and Plastic Surgery, West China Hospital)
Abstract:
【Abstract】 Fibrotic disease is a common clinical disease and the treatment is still a problem. Peroxisome proliferator activated receptorγ(PPARγ) is a subtype of peroxisome proliferatoractivated receptors(PPARs). Recent studies have found that PPARγ′s activators or agonists have a moderating effect in the occurrence of organ fibrosis, it may slow fibrotic process. In this article, we reviewed medical literatures related to PPARγ and fibrotic diseases in liver, kidney, lung, heart, eyes, skin and other organ.
Key words:  Peroxisome proliferator activated receptor γ  Hepatic fibrosis  Renal fibrosis  Pulmonary fibrosis  Skin fibrosis

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