【Abstract】 Fibrotic disease is a common clinical disease and the treatment is still a problem. Peroxisome proliferator activated receptorγ(PPARγ) is a subtype of peroxisome proliferatoractivated receptors(PPARs). Recent studies have found that PPARγ′s activators or agonists have a moderating effect in the occurrence of organ fibrosis, it may slow fibrotic process. In this article, we reviewed medical literatures related to PPARγ and fibrotic diseases in liver, kidney, lung, heart, eyes, skin and other organ.