【Abstract】 Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid. They play an important role in mammal organs including human especially in hearts by modulating ion transportation, gene expression, activating signal transduction pathways and binding to putative EETs receptors which result in the resistance of coronary circulation reduced, antiapoptotic and the recovery of functional in postischemia improved, etc. The EETs mediated myocardial protection during myocardial ischemia/ reperfusion injury and the mechanisms are reviewed in this paper.