【Abstract】 Objective To evaluate the clinical effects of minimally transforaminal interbody fusion for treating lumbar degenerative disease. Methods 96 patients with lumbar degenerative disease from February 2010 to February 2015 in our hospital were divided into the treatment group and the control group based on the random number table. The treatment group were received minimally invasive transforaminal Quadrant interbody fusion, and the control group were received open transforaminal lumbar interbody fusion. Results All patients were successfully operated and with Ⅰ incision healing. The incision length, blood loss, postoperative drainage and postoperative hospital stay in the treatment group were significantly less than that of the control group (P＜005). The postoperative 3month neurological function were significantly better than the preoperative (P＜005), while the postoperative 3month neurological function in the treatment group were significantly better than that of the control group (P＜005). The postoperative 3month Oswestry Disability scores in the treatment group and control group were 1345±418 and 2198±514, which were significantly lower than the preoperative (3298±411, 3308±408) (P＜005). The postoperative 3month bedsores, pneumothorax, cerebrospinal fluid leakage, gastrointestinal reactions in the treatment group were significantly less than that of the control group (P＜005). Conclusion Minimally invasive transforaminal lumbar interbody fusion for treating lumbar degenerative disease can promote the recovery of renal function and lumbar spinal cord, it has good security that is conducive to the rehabilitation of patients.