【Abstract】 Objective To observe and explore the effect of sodium fructose diphosphate on myocardial protection in surgical patients with myocardial ischemia at perioperative period. Methods 86 patients ready to surgery with myocardial ischemia were divided into trail group and control group. Trail group was treated with sodium fructose diphosphate (20g/d) for 7 days before surgery. Mean arterial pressure, cardiac output, the serum concentration of ischemia modified albumin, hearttype fatty acidbinding protein and cardiac troponinT were all measured at four different time points in two groups, including before treatment, before anesthesia, before and after tube drawing. The total operation time and arrhythmia onset were recorded in two groups. Results The mean arterial pressure and cardiac output were obviously higher in the sodium fructose diphosphate treatment group than the control group before anesthesia, before and after tube drawing, yet the serum concentration of ischemia modified albumin, hearttype fatty acidbinding protein and cardiac troponinT significantly lower. Besides, the serum concentration of ischemia modified albumin in the trail group was sharply lower in operation than before treatment, while in the control group apparently higher. Meanwhile, the incidence of arrhythmia in operation was less in sodium fructose diphosphate treatment group than the control group. Conclusion Sodium fructose diphosphate has significant protective effect on ischemic myocardium at perioperative period.