【Abstract】 Objective To investigate the change of FOXP3+ regulatory T cells (Tregs) in patients with systemic sclerosis (SSc) using metaanalysis. Methods The databases including PubMed, Wanfang, Weipu and CNKI were searched for relevant studies up to September 30, 2016. After data extraction for included studies, a metaanalysis was performed using RevMan 5.3. Results 8 studies with 393 subjects met the inclusion criteria for present analysis. The result of metaanalysis showed that compared with healthy controls, the radio of FOXP3+Treg of CD4+ T cells in peripheral blood mononuclear cells (PBMCs) of SSc patients increased by 040% for the CD4+CD25+/highFOXP3+Tregs［WMA=040，95%CI（014，065）］. Conclusion Based on the current evidences, the immunedysfunction of SSc may be due to the increase of FOXP3+Treg in circulation.