【Abstract】 The construction of chest pain center in our country has been initiated and rapidly progressing in recent years which seeks to build up a green passage for the emergency treatment in patients who present with “chest pain”. Acute coronary syndrome (ACS) has experienced an steep augmentation in morbidity. We prioritize the effective revascularization therapy in treating patients diagnosed with ACS, especially STsegment elevation myocardial infarction (STEMI) in which nonpercutaneous coronary intervention (nonPCI ) therapy hospitals have exerted tremendous effects. Chest pain center has established high efficiency regional collaborative aiding network with the “ one supports all” pattern which has been gradually ameliorated in a national scale and accomplished primary achievements. This article aims to elaborate the construction of chest pain center and the impact generated by nonPCI hospitals in establishing ACS regional collaborative aiding network.